SARM
S-23
SaveA potent oral SARM studied in rodent models as a potential male hormonal contraceptive due to its strong suppression of gonadotropins and spermatogenesis.
Quick verdict
Among the most potent SARMs in animal models but also the most suppressive. No published human data.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Rat studies showed full reversible azoospermia alongside significant muscle and bone gains. Potency approaches that of androgens but with substantial hormonal suppression, blurring the line between SARM and anabolic steroid.
Benefits
- Strong anabolic effects in rodent models
- Reversible contraceptive effect in male rats
- Oral bioavailability demonstrated preclinically
Dosage notes
No human dosing established. Rodent studies used 0.1–3 mg/kg.
Side effects
- Near-complete gonadal suppression in animals
- Prostate effects at higher doses
Who should be cautious
Extremely suppressive to the hypothalamic-pituitary-gonadal axis in animals. No human safety data. Not approved for any use.
What this page cannot tell you
The high degree of suppression challenges the concept of tissue selectivity. All data is preclinical.
Leaderboard scores
- Muscle45
- Libido10
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