Supplement
S-Acetyl Glutathione
SaveS-acetyl glutathione is an acetylated, orally stable form of glutathione that resists degradation in the GI tract and may deliver intact glutathione to cells.
Quick verdict
Theoretically superior oral bioavailability over reduced glutathione, but clinical evidence comparing forms is limited.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Acetylation protects the sulfhydryl group from oxidation and enzymatic breakdown. Pharmacokinetic data suggests better absorption than reduced glutathione, but head-to-head clinical trials are scarce.
Benefits
- Improved oral stability over reduced glutathione
- Supports cellular antioxidant defense
- May enhance detoxification pathways
Dosage notes
100–300 mg daily on an empty stomach.
Side effects
- Sulfurous taste or smell
- Mild GI discomfort
- Temporary detox symptoms
Who should be cautious
Generally safe. Some individuals report detox-like symptoms when starting.
What this page cannot tell you
Liposomal glutathione is another bioavailable option. Direct clinical comparisons between delivery forms are lacking.
Leaderboard scores
- Longevity45
- Immunity40
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