Salicin

Moderate evidence for low back pain. Gentler on the stomach than aspirin but slower onset.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Several RCTs support willow bark extract (standardized to salicin) for low back pain at 120–240 mg salicin daily. Mechanism includes COX inhibition and other anti-inflammatory pathways beyond salicylic acid alone.

• Natural analgesic for low back pain
• Anti-inflammatory via multiple pathways
• Gentler on gastric mucosa than aspirin

Willow bark extract providing 120–240 mg salicin daily.

• GI irritation (less than aspirin)
• Allergic reactions in aspirin-sensitive individuals
• Potential bleeding risk

Avoid in aspirin allergy, children (Reye syndrome risk), and with anticoagulants. Not a direct aspirin substitute for cardiovascular prevention.

Willow bark contains additional bioactives that may contribute to effects beyond salicin alone. Onset is slower than aspirin.

• Pain55
• Recovery35