Peptide
Selank
SaveA synthetic heptapeptide analog of the immunomodulatory peptide tuftsin, developed in Russia and approved there as an anxiolytic and nootropic nasal spray.
Quick verdict
Approved in Russia for generalized anxiety. Mechanism involves GABA, serotonin, and BDNF modulation. Not evaluated by Western regulators.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Several Russian clinical trials support anxiolytic efficacy comparable to benzodiazepines without sedation or dependence. Limited international replication.
Benefits
- Anxiolytic effects without sedation or dependence potential
- BDNF upregulation and nootropic properties reported
- Immunomodulatory effects from tuftsin backbone
Dosage notes
Russian approved dose: 0.15% nasal spray, 2–3 drops per nostril, 3 times daily for 14 days.
Side effects
- Nasal irritation
- Mild fatigue
- Headache occasionally
Who should be cautious
Approved only in Russia. Western regulatory evaluation has not occurred. Product sourcing outside Russia may be unreliable.
What this page cannot tell you
Clinical data are predominantly Russian. Independent replication in Western trials would strengthen the evidence considerably.
Leaderboard scores
- Anxiety45
- Stress40
- Focus28
- Mood25
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