Peptide
Semax
SaveA synthetic heptapeptide analog of ACTH (4-10) with an added Pro-Gly-Pro sequence, approved in Russia as a nootropic and neuroprotective nasal spray.
Quick verdict
Approved in Russia for cognitive impairment and stroke recovery. Upregulates BDNF and modulates monoamine systems. Not evaluated by Western regulators.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Russian clinical trials and approved uses include stroke recovery, cognitive impairment, and optic nerve disease. BDNF upregulation is well documented. Limited Western data.
Benefits
- BDNF upregulation well documented
- Approved for post-stroke cognitive recovery in Russia
- Nootropic and neuroprotective properties reported
- Non-sedating with no dependence potential
Dosage notes
Russian approved dose: 0.1% nasal spray, 2–3 drops per nostril 2–3 times daily. Higher-dose 1% formulation exists for stroke.
Side effects
- Nasal irritation
- Headache
- Irritability at higher doses
Who should be cautious
Approved only in Russia. May modulate the HPA axis at higher doses. Product quality from non-Russian sources varies.
What this page cannot tell you
Strong Russian clinical data but lacking independent Western replication. Publication bias is possible.
Leaderboard scores
- Focus42
- Memory38
- Mood22
- Energy20
Write a review
Sign in to write a review.