Supplement
Serrapeptase
SaveSerrapeptase is a proteolytic enzyme originally derived from silkworm bacteria, used for inflammation, pain, and mucus reduction.
Quick verdict
Popular in integrative medicine but clinical evidence is mixed and largely from lower-quality trials.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Some small trials support post-surgical swelling reduction and sinusitis symptom relief. Systematic reviews note poor study quality. Widely used in Europe and Japan but evidence base is weaker than for bromelain.
Benefits
- May reduce post-surgical swelling
- Used for sinus congestion and mucus
- Anti-inflammatory properties claimed
Dosage notes
10,000–120,000 SPU (serrapeptase units) daily on an empty stomach. Enteric-coated formulations required.
Side effects
- GI disturbance
- Increased bleeding risk
- Skin reactions (rare)
- Pneumonitis (rare case reports)
Who should be cautious
May increase bleeding risk. Avoid before surgery and with anticoagulants. Rare reports of pneumonitis.
What this page cannot tell you
Many studies are old, small, and of questionable methodology. Enteric coating is essential for activity.
Leaderboard scores
- Pain35
- Recovery35
- Immunity25
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