Sodium Butyrate

Strong biological rationale for gut health. Clinical evidence for oral supplementation is growing but still moderate.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Butyrate is well-established as essential for colonocyte health and gut barrier function. Oral supplementation studies show benefits for IBS symptoms and inflammatory markers. Also an HDAC inhibitor with epigenetic implications.

• Primary fuel source for colon cells
• Supports gut barrier integrity
• HDAC inhibitor with anti-inflammatory effects
• May improve IBS symptoms

150–600 mg daily. Enteric-coated or delayed-release forms preferred to reach the colon.

• Strong unpleasant odor and taste
• GI discomfort
• Bloating

Unpleasant taste and smell. Enteric-coated forms preferred. Limited long-term safety data for supplemental doses.

Endogenous butyrate production from fiber fermentation may be more physiologically relevant than oral supplementation. Tributyrin may be a superior delivery form.

• Immunity45
• Longevity40