Sulforaphane

One of the most promising chemopreventive and cytoprotective compounds from food. Clinical evidence is solid for detoxification and anti-inflammatory endpoints.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Clinical trials demonstrate enhanced detoxification of airborne pollutants (benzene, acrolein), reduced markers of inflammation, and improved blood glucose in type 2 diabetes. Nrf2 activation is well-documented across multiple tissue types.

• Potent Nrf2 activator and cytoprotective agent
• Enhances Phase II detoxification
• Anti-inflammatory across multiple pathways
• May support blood glucose regulation

10–40 mg sulforaphane daily, or 100–400 mg glucoraphanin with myrosinase. Broccoli sprouts are the richest natural source.

• GI gas and bloating
• Thyroid concerns at extreme doses (goitrogens)
• Mild heartburn

May interact with drugs metabolized by CYP enzymes. Raw broccoli sprouts carry food safety risk (E. coli, Salmonella).

Myrosinase enzyme is required to convert glucoraphanin to sulforaphane. Supplements vary in whether they provide preformed sulforaphane or require conversion.

• Longevity65
• Immunity50