Supplement
Tocotrienols
SaveTocotrienols are the lesser-known form of vitamin E with unique neuroprotective, cardiovascular, and anti-inflammatory properties not shared by tocopherols.
Quick verdict
Emerging evidence suggests benefits beyond standard vitamin E, particularly for arterial health and brain protection. Research is growing.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Clinical trials show reduction in carotid artery stenosis progression, cholesterol-lowering (via HMG-CoA reductase), and neuroprotective effects. Annatto-derived tocotrienols (delta and gamma) are tocopherol-free and may be most effective.
Benefits
- May slow carotid artery stenosis
- Neuroprotective properties distinct from tocopherols
- Cholesterol-lowering via HMG-CoA reductase
- Potent antioxidant at the cell membrane level
Dosage notes
100–300 mg daily of mixed tocotrienols or delta-tocotrienol. Take with fat-containing meal.
Side effects
- Generally well tolerated
- Mild GI discomfort
- Potential interaction with anticoagulants
Who should be cautious
High doses of alpha-tocopherol can deplete tocotrienols. Take separately from alpha-tocopherol supplements by 6+ hours.
What this page cannot tell you
The vitamin E field is complex; not all tocotrienol forms are equivalent. Annatto-derived (delta/gamma) may differ from palm-derived (mixed).
Leaderboard scores
- Longevity50
- Memory35
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