Peptide
TRH
SaveThyrotropin-Releasing Hormone, a tripeptide (pyroGlu-His-Pro-NH2) from the hypothalamus that stimulates TSH and prolactin release. Used diagnostically.
Quick verdict
Well-characterized endocrine hormone with approved diagnostic use. Also studied for depression and consciousness disorders with mixed results.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Established diagnostic tool for pituitary TSH reserve testing. Research interest in depression (rapid transient antidepressant effect) and disorders of consciousness. Therapeutic utility limited by short half-life.
Benefits
- Established diagnostic tool for thyroid-pituitary axis assessment
- Rapid transient antidepressant effect documented
- Research interest in arousal and consciousness
Dosage notes
Diagnostic: 200–500 mcg IV. Research use only for other indications.
Side effects
- Nausea
- Urgency to urinate
- Flushing
- Transient hypertension
- Metallic taste
Who should be cautious
Transient blood pressure increase and nausea with IV injection. Not for chronic use.
What this page cannot tell you
Diagnostic utility is clear. Therapeutic antidepressant effects are transient (hours) and not practical for chronic treatment.
Leaderboard scores
- Mood18
- Energy15
Write a review
Sign in to write a review.