Supplement
Tributyrin
SaveTributyrin is a triglyceride form of butyric acid that delivers butyrate more efficiently to the lower GI tract compared to sodium butyrate.
Quick verdict
Superior delivery form for butyrate supplementation. Clinical evidence is growing and supports gut health applications.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Pharmacokinetic studies show tributyrin achieves 3–5x higher plasma butyrate than sodium butyrate. Preclinical data is strong for gut barrier function, inflammation, and HDAC inhibition. Clinical trials are underway.
Benefits
- Superior butyrate delivery to lower GI tract
- Supports gut barrier integrity
- HDAC inhibitor with anti-inflammatory effects
Dosage notes
150–1000 mg daily. Often dosed at 300–500 mg twice daily.
Side effects
- Butyric acid odor (milder than sodium butyrate)
- GI discomfort
- Burping
Who should be cautious
Generally well tolerated. Limited long-term safety data.
What this page cannot tell you
Fewer published clinical trials than sodium butyrate despite theoretical advantages. More research needed.
Leaderboard scores
- Immunity45
- Longevity40
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