Supplement
Trigonelline
SaveTrigonelline is an alkaloid found in coffee and fenugreek seeds, recently identified as an NAD+ precursor that declines with aging and may support muscle health.
Quick verdict
Newly identified NAD+ booster with exciting preclinical data for sarcopenia. Human longevity evidence is preliminary.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
A 2024 Nature Metabolism study identified trigonelline as declining with age and correlating with sarcopenia. Supplementation restored NAD+ and improved muscle function in aged mice. Human trials are in early stages.
Benefits
- NAD+ precursor that declines with aging
- May support muscle health in aging
- Naturally present in coffee and fenugreek
Dosage notes
No established supplemental dose. Coffee provides approximately 40–100 mg per cup.
Side effects
- Insufficient data for comprehensive safety profile
- GI discomfort possible
Who should be cautious
Very early in clinical development. Optimal dosing and safety profile not established.
What this page cannot tell you
The NAD+ precursor space is crowded (NMN, NR). Comparative efficacy with established precursors is unknown.
Leaderboard scores
- Longevity40
- Muscle30
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