Nootropic
Unifiram
SaveA synthetic AMPAkine closely related to sunifiram, reported to be similarly potent in rodent memory paradigms. No human clinical data exists.
Quick verdict
Nearly identical profile to sunifiram — potent rodent data, zero human evidence, and meaningful safety unknowns.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Active in passive-avoidance and Morris water-maze paradigms in mice at very low doses. Proposed mechanism is AMPA receptor positive modulation. Published data is limited to a handful of Italian research papers.
Benefits
- Anti-amnesic effects in rodent models at microgram doses
- Proposed AMPA-receptor positive modulation
Dosage notes
No validated human dose. Online reports suggest 2–10 mg sublingually.
Side effects
- Unknown — no human data
- Theoretical excitotoxicity risk
Who should be cautious
No human safety profile. Theoretical seizure risk from excessive AMPA potentiation. Not approved or regulated.
What this page cannot tell you
Even less studied than sunifiram. The total published literature amounts to a few preclinical papers.
Leaderboard scores
- Memory20
- Focus15
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