Supplement
Uridine
SaveUridine is a pyrimidine nucleoside involved in RNA synthesis, neuronal membrane phospholipid formation, and dopamine signaling, studied for cognitive and mood support.
Quick verdict
Interesting nootropic with strong biological rationale. Clinical evidence is limited but growing, especially in combination with DHA and choline.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Synergistic with DHA and choline for synaptic membrane synthesis (Kennedy Pathway). Small clinical studies suggest benefits in mood disorders (bipolar depression). Uridine monophosphate (UMP) is the preferred oral form.
Benefits
- Supports neuronal membrane phospholipid synthesis
- Synergistic with DHA and choline for brain health
- May modulate dopamine release
- Potential mood-stabilizing effects
Dosage notes
150–500 mg uridine monophosphate (UMP) daily. Often stacked with DHA and choline.
Side effects
- GI discomfort
- Headache (uncommon)
- Fatigue at high doses
Who should be cautious
Limited safety data for long-term supplementation. Theoretically could promote tumor growth due to nucleotide role in DNA/RNA synthesis.
What this page cannot tell you
Most promising when combined with DHA and choline. Isolated uridine supplementation is less studied.
Leaderboard scores
- Mood40
- Memory38
- Focus35
Write a review
Sign in to write a review.