Nootropic
Vinpocetine
SaveA semi-synthetic derivative of vincamine from the periwinkle plant (Vinca minor). Used in Europe and Asia for cerebrovascular disorders and cognitive decline.
Quick verdict
Decades of clinical use in Europe with a reasonable safety profile. Evidence for cognitive enhancement is modest and mostly in cerebrovascular populations.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Inhibits PDE1 and voltage-gated sodium channels, increases cerebral blood flow and glucose utilization. A Cochrane review found insufficient evidence to recommend for dementia, though individual trials show modest positive effects. Widely prescribed in Eastern Europe and Asia.
Benefits
- Increases cerebral blood flow and glucose metabolism
- Long clinical track record in Europe
- Anti-inflammatory and neuroprotective properties in preclinical models
Dosage notes
5–10 mg three times daily with meals (typical clinical dosing). Higher doses have been used in research settings.
Side effects
- Headache
- Facial flushing
- GI discomfort
- Dizziness
Who should be cautious
FDA warning against use during pregnancy (potential fetal harm). May increase bleeding risk. Avoid combining with anticoagulants.
What this page cannot tell you
Cochrane review was inconclusive. Heterogeneity in preparations and study quality makes definitive conclusions difficult.
Leaderboard scores
- Memory45
- Focus40
- Longevity25
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