Supplement
Vitamin B2 (Riboflavin)
SaveRiboflavin is an essential B vitamin that serves as a precursor to FAD and FMN, coenzymes critical for energy production, antioxidant recycling, and drug metabolism.
Quick verdict
Evidence-based for migraine prevention at 400 mg daily. Otherwise mainly relevant for deficiency correction.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Multiple RCTs support 400 mg riboflavin for migraine prophylaxis. Essential for glutathione recycling and mitochondrial electron transport. Deficiency is common globally and in older adults.
Benefits
- Clinically proven migraine prophylaxis at 400 mg
- Essential for FAD/FMN-dependent enzymes
- Supports glutathione recycling and antioxidant defense
Dosage notes
RDA is 1.1–1.3 mg. Migraine prophylaxis: 400 mg daily. Split doses improve absorption.
Side effects
- Bright yellow urine (harmless)
- Diarrhea at very high doses
Who should be cautious
Very safe. High doses cause harmless bright yellow urine (flavinuria). No known toxicity.
What this page cannot tell you
Absorption plateaus around 27 mg per single dose. For migraine, high-dose effects may involve mechanisms beyond simple nutrient repletion.
Leaderboard scores
- Pain50
- Energy40
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