Vitamin B3 (Niacin)

Nicotinic acid is proven for lipid modulation. Niacinamide supports skin and joints. NR and NMN are NAD+ boosters for longevity research.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Nicotinic acid robustly raises HDL and lowers triglycerides but AIM-HIGH and HPS2-THRIVE trials questioned cardiovascular mortality benefit. Niacinamide studied for osteoarthritis and skin. NAD+ precursor forms (NR, NMN) are rapidly advancing.

• Potent HDL-raising and triglyceride-lowering (nicotinic acid)
• NAD+ precursor supporting cellular energy
• Niacinamide benefits for skin and joints

RDA is 14–16 mg NE. Lipid doses: 1–3 g nicotinic acid. Niacinamide: 500–1500 mg. NR/NMN: see specific entries.

• Flushing (nicotinic acid)
• Liver enzyme elevation at high doses
• GI discomfort
• Blood glucose elevation

Nicotinic acid causes flushing and can elevate liver enzymes and blood glucose. Extended-release forms reduce flushing but increase hepatotoxicity risk.

Different forms have very different profiles. Nicotinic acid, niacinamide, NR, and NMN should not be considered interchangeable.

• Longevity55
• Energy50