Supplement
Vitamin B6 (Pyridoxine)
SavePyridoxine is the most common supplemental form of vitamin B6, converted in the liver to the active coenzyme P5P for neurotransmitter synthesis and amino acid metabolism.
Quick verdict
Essential with broad metabolic roles. Effective for morning sickness and PMS. Chronic high doses carry neuropathy risk.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Well-established for nausea of pregnancy, carpal tunnel (debated), PMS symptoms, and homocysteine lowering. Chronic intake above 100 mg/day can cause sensory neuropathy. P5P form may be safer at high doses.
Benefits
- Supports over 100 enzymatic reactions
- Effective for pregnancy-related nausea
- Essential for neurotransmitter synthesis
- Reduces homocysteine levels
Dosage notes
RDA is 1.3–2.0 mg. Therapeutic doses up to 50–100 mg. Do not exceed 100 mg long-term without supervision.
Side effects
- Peripheral neuropathy at chronic high doses
- Photosensitivity
- GI discomfort
Who should be cautious
Peripheral neuropathy reported at chronic doses above 100–200 mg/day. Symptoms include numbness and tingling. Usually reversible on discontinuation.
What this page cannot tell you
P5P is the active form and may be preferred for those needing higher doses or with impaired liver conversion.
Leaderboard scores
- Mood50
- Energy45
- Focus35
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