Vitamin B8 (Inositol)

Robust evidence for PCOS and panic disorder. One of the better-supported supplements for anxiety. High doses required for effect.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Multiple RCTs support myo-inositol for PCOS (ovulation, insulin sensitivity, androgen levels). Meta-analyses confirm efficacy comparable to SSRIs for panic disorder. D-chiro-inositol also relevant for PCOS at lower doses.

• Improves insulin sensitivity in PCOS
• Reduces anxiety and panic attack frequency
• Supports ovulation and hormonal balance
• Second-messenger role in serotonin signaling

PCOS: 2000–4000 mg myo-inositol daily. Anxiety/panic: 12,000–18,000 mg daily in divided doses.

• GI discomfort at high doses
• Nausea
• Flatulence

High doses (12–18 g) can cause GI side effects. Myo:D-chiro ratio matters for PCOS (typically 40:1).

Not technically a vitamin despite the B8 designation. Effective doses for anxiety (12–18 g) are much higher than for PCOS (2–4 g).

• Anxiety65
• Mood55
• Stress45