Supplement
Vitamin B9 (Folate)
SaveFolate is an essential B vitamin required for DNA synthesis, methylation, and neural tube development. Methylfolate (5-MTHF) is the biologically active form.
Quick verdict
Critical for pregnancy and methylation. Methylfolate preferred over folic acid for those with MTHFR polymorphisms.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Unequivocal evidence for neural tube defect prevention. Essential for DNA synthesis and one-carbon metabolism. MTHFR C677T polymorphism affects folic acid conversion; 5-MTHF bypasses this. Excessive folic acid may mask B12 deficiency.
Benefits
- Prevents neural tube defects in pregnancy
- Essential for DNA synthesis and repair
- Supports methylation and homocysteine metabolism
- Critical for red blood cell production
Dosage notes
RDA is 400 mcg DFE (600 mcg in pregnancy). Methylfolate 400–1000 mcg for general supplementation.
Side effects
- May mask B12 deficiency symptoms (folic acid form)
- GI discomfort at high doses
- Insomnia (methylfolate, rare)
Who should be cautious
High-dose folic acid (>1 mg) may mask B12 deficiency. Potential concern about unmetabolized folic acid and cancer risk at high chronic doses.
What this page cannot tell you
5-MTHF (methylfolate) is preferred for supplementation, especially for MTHFR carriers. Folinic acid is another active option.
Leaderboard scores
- Longevity50
- Mood45
- Energy40
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