Supplement
Xanthohumol
SaveXanthohumol is a prenylated chalcone from hops with broad preclinical activity including anti-cancer, anti-inflammatory, and metabolic syndrome modulation.
Quick verdict
Promising preclinical multi-target compound. Human evidence is emerging but limited to small trials.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Preclinical studies demonstrate anti-proliferative, anti-angiogenic, and lipid-lowering effects. A phase I human trial confirmed safety and showed improved metabolic markers. Larger efficacy trials are needed.
Benefits
- Broad-spectrum anti-inflammatory activity
- Preclinical anti-cancer properties
- May improve metabolic syndrome markers
Dosage notes
12–24 mg daily in human studies. Derived from hops extract.
Side effects
- GI discomfort
- Potential estrogenic metabolite production
- Limited long-term data
Who should be cautious
Estrogenic metabolites (8-prenylnaringenin) may be produced. Use with caution in hormone-sensitive conditions.
What this page cannot tell you
Beer is a very poor source (concentrations are too low). Supplemental doses are needed for bioactivity.
Leaderboard scores
- Longevity30
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