Mood Support Stack

Aimed at supporting serotonergic tone, reducing neuroinflammation, and improving subjective well-being. Saffron and SAMe have the strongest controlled-trial evidence for low mood among natural compounds. This stack is not a replacement for therapy, lifestyle changes, or prescribed medication — it is a complementary layer. Onset varies: some compounds act within days, others need 4–6 weeks. Effects differ by individual.

• saffron

  30 mg standardized extract daily

• same

  400–800 mg/day on empty stomach; start at 200 mg

• omega-3

  1–2 g EPA-dominant fish oil daily

• 5-htp

  50–100 mg before bed; do not combine with SSRIs

• st-johns-wort

  300 mg 3×/day standardized to 0.3% hypericin; many drug interactions — check carefully