Saffron

One of the best-supported mood herbs, with several trials showing antidepressant effects comparable to standard medication in mild-to-moderate cases.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Multiple randomized trials and reviews support saffron for depressive symptoms, anxiety, and possibly snacking or appetite control. Standardization for crocin and safranal matters.

• May improve mood and emotional resilience
• Has some support for anxiety reduction
• Can modestly reduce snacking and appetite in some users

Most clinical studies use around 28-30 mg/day of standardized saffron extract.

• Headache
• Nausea
• Dizziness

Authenticity is a real issue because saffron is expensive and frequently adulterated. Very high doses are not safe in pregnancy.

The strongest data is in standardized extracts and mild-to-moderate symptom ranges, not in severe mood disorders.

• Mood65
• Weight loss30
• Anxiety30
• Sleep20