Supplement
Alpha-lipoic acid
SaveAn endogenous dithiol compound that functions as a cofactor in mitochondrial energy metabolism and as a potent recycler of other antioxidants.
Quick verdict
Well-supported for diabetic neuropathy. Antioxidant and blood-sugar effects are real but modest in healthy populations.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
The ALADIN and SYDNEY trials established efficacy in diabetic polyneuropathy at 600 mg IV/oral. Oral supplementation shows mild glucose-lowering effects in meta-analyses.
Benefits
- Clinically supported for diabetic neuropathy
- Recycles vitamins C and E and glutathione
- Mild blood-sugar modulating effect
Dosage notes
300–600 mg/day orally for general use; 600 mg/day is the studied dose for neuropathy.
Side effects
- Nausea on an empty stomach
- Skin rash (rare)
- Hypoglycaemia risk with diabetes medications
Who should be cautious
Can lower blood sugar; diabetics on medication should monitor closely. Rare reports of insulin autoimmune syndrome in susceptible individuals.
What this page cannot tell you
R-ALA is the bioactive enantiomer but is less stable; many products use racemic mixtures. IV data don't fully translate to oral dosing.
Leaderboard scores
- Longevity55
- Pain50
- Recovery45
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