Supplement
Apigenin
SaveA flavone found in chamomile, celery, and parsley that acts as a mild anxiolytic and CD38 inhibitor, gaining attention for NAD+ preservation and sleep.
Quick verdict
Low-risk flavonoid with plausible sleep and NAD+ benefits. Evidence is mostly preclinical but the safety profile is favourable.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
In vitro CD38 inhibition may spare NAD+. Chamomile extract trials (where apigenin is a key component) show modest anxiolytic and sleep-quality effects. Direct apigenin-only RCTs in humans are scarce.
Benefits
- May preserve NAD+ via CD38 inhibition
- Mild anxiolytic properties
- Favourable safety profile from food-level intake
Dosage notes
50–100 mg before bed is a commonly used range. Andrew Huberman popularised 50 mg for sleep.
Side effects
- Sedation at higher doses
- Possible CYP interactions (theoretical)
Who should be cautious
High doses may have mild sedative effects. Theoretical concern about CYP enzyme interactions at pharmacological doses.
What this page cannot tell you
Most human data use chamomile extract, not isolated apigenin. NAD+ preservation is extrapolated from cell culture.
Leaderboard scores
- Sleep48
- Anxiety40
- Longevity35
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