Supplement
Chondroitin
SaveA glycosaminoglycan component of cartilage, often combined with glucosamine for osteoarthritis. Trial results are inconsistent.
Quick verdict
Large trials (GAIT) showed no clear benefit over placebo for most OA patients. European guidelines are more favourable than American ones. Individual response varies.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
The NIH-funded GAIT trial found no significant benefit vs placebo for the primary endpoint. European trials (STOPP, Monfort) are more positive. Pharmaceutical-grade chondroitin sulfate (Condrosulf) performs better than unregulated products.
Benefits
- Structural component of cartilage
- Some trials show reduced OA pain and joint-space narrowing
- Well-tolerated long-term
Dosage notes
800–1200 mg/day of chondroitin sulfate. Pharmaceutical-grade products have better data.
Side effects
- Mild GI upset
- Rare allergic reactions
Who should be cautious
Quality varies enormously—some products contain little actual chondroitin. Shellfish-derived forms may be an allergen concern.
What this page cannot tell you
Pharmaceutical-grade vs supplement-grade quality matters greatly. European vs US trial results diverge, possibly due to product quality.
Leaderboard scores
- Pain38
- Recovery32
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