Amino Acid
Citrulline malate
SaveA 2:1 compound of L-citrulline and malic acid, widely used in pre-workout supplements. The malate component may contribute to aerobic energy production via the TCA cycle.
Quick verdict
The most commonly studied form for exercise performance. Benefits appear slightly greater than citrulline alone, possibly due to the malate contribution.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Several studies show increased repetitions to failure in resistance exercise (typically 1–3 extra reps per set) and reduced muscle soreness 24–48 hours post-exercise. The contribution of malate versus citrulline alone is not well isolated in most trials.
Benefits
- Increased repetitions to failure in resistance training
- Reduced delayed-onset muscle soreness
- Malic acid may support aerobic energy production
Dosage notes
6–8 g taken 30–60 minutes before exercise. Look for 2:1 citrulline-to-malate ratio.
Side effects
- Mild GI discomfort
- Sour taste
Who should be cautious
Generally well tolerated. Verify the ratio — some products labeled citrulline malate contain less than the 2:1 ratio used in studies.
What this page cannot tell you
It is unclear how much of the benefit comes from malate versus citrulline. The 2:1 ratio means 8 g of citrulline malate provides roughly 5.3 g of citrulline.
Leaderboard scores
- Recovery45
- Muscle40
- Energy35
Featured in protocols
- Energy & Endurance Stackadjunct
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