Hyaluronic Acid

Reasonable evidence for skin hydration and mild joint comfort improvement. Oral bioavailability was once questioned but appears sufficient at higher molecular weights.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Multiple RCTs demonstrate that oral hyaluronic acid (80-200 mg/day) can improve skin moisture and reduce wrinkles over 6-12 weeks. Joint studies show modest pain reduction in knee osteoarthritis. Labeled studies using isotope-tagged HA confirm oral absorption and tissue distribution.

• Improves skin hydration and elasticity
• May reduce joint discomfort in mild osteoarthritis
• Supports connective tissue moisture retention

Oral doses of 80-200 mg daily, typically for at least 8-12 weeks to see benefits. Both low and high molecular weight forms have shown effects.

• Generally very well-tolerated
• Rare mild GI upset

Theoretical concern about promoting cancer cell migration in those with active malignancy. Generally well-tolerated.

Molecular weight of the supplement affects absorption and distribution. Benefits are modest and require consistent use over weeks.

• Pain40
• Recovery30
• Longevity30