Nootropic
Lion's Mane
SaveAn edible medicinal mushroom (Hericium erinaceus) containing hericenones and erinacines that stimulate nerve growth factor synthesis in vitro and in animal models.
Quick verdict
Small human trials suggest modest cognitive benefits in older adults with mild impairment. Broader claims about neurogenesis in healthy young adults outrun current data.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
A 2009 Japanese RCT (n=30) in adults with mild cognitive impairment showed improvements on a cognitive scale over 16 weeks. A few smaller trials show anxiolytic and mood effects. NGF stimulation is well-demonstrated in vitro but CNS relevance of oral dosing is unclear.
Benefits
- May improve cognitive function in older adults with mild impairment
- Stimulates NGF synthesis in preclinical models
- Generally well tolerated
Dosage notes
500–1000 mg of extract (standardized to hericenones/erinacines) twice daily with meals.
Side effects
- GI discomfort
- Skin rash in sensitive individuals
Who should be cautious
Rare allergic reactions, especially in individuals with mushroom sensitivities. Theoretical concern about worsening asthma.
What this page cannot tell you
NGF does not readily cross the blood-brain barrier; oral mushroom extract stimulating central NGF is plausible but unconfirmed in humans.
Leaderboard scores
- Memory55
- Focus50
- Mood45
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