MSM (Methylsulfonylmethane)

Moderate evidence for joint pain relief in osteoarthritis and exercise recovery. Well-tolerated with a good safety profile.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

Several RCTs show MSM reduces joint pain and improves physical function in knee osteoarthritis, though effect sizes are generally modest. May reduce exercise-induced muscle damage and oxidative stress. Provides bioavailable sulfur for glutathione synthesis and connective tissue maintenance. Often combined with glucosamine.

• Reduces joint pain and inflammation in osteoarthritis
• Provides bioavailable sulfur for connective tissue and glutathione
• May reduce exercise-induced muscle damage and soreness

1500-6000 mg daily in divided doses. Most OA studies use 1500-3000 mg daily. May take 2-4 weeks for noticeable effects.

• GI discomfort at higher doses
• Bloating
• Headache (usually transient)

Well-tolerated. May have mild blood-thinning effects. Quality varies between products.

Effect sizes in OA trials are modest. Many positive studies are industry-funded. Optimal dose and duration for different conditions are not well-established.

• Pain45
• Recovery40
• Muscle25