Phosphatidylserine

Moderate evidence for age-related cognitive decline and exercise-induced cortisol blunting. Generally well-tolerated.

A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.

FDA-qualified health claim for cognitive decline risk reduction (limited evidence). Multiple trials show improvements in memory and attention in older adults. Cortisol-lowering effects seen at 600–800 mg.

• Supports memory and cognitive function in aging
• May blunt cortisol response to exercise
• Maintains neuronal membrane fluidity

100–300 mg daily for cognitive support. 400–800 mg for cortisol modulation.

• Insomnia at high doses
• GI discomfort
• May increase effect of blood thinners

Modern supplements use soy or sunflower-derived PS (not bovine cortex). May interact with blood thinners.

Earlier studies used bovine-derived PS which may have different efficacy than plant-derived forms.

• Memory60
• Focus50
• Stress45
• Recovery35