Supplement
Spermidine
SaveSpermidine is a natural polyamine that induces autophagy and is associated with longevity in observational studies across multiple populations.
Quick verdict
Exciting longevity candidate with strong epidemiological and mechanistic data. Human intervention trials are in early stages.
Evidence score
A rough internal score reflecting quantity, quality, and consistency of human evidence. Not a clinical recommendation.
What the research shows
Epidemiological studies link dietary spermidine intake to reduced cardiovascular mortality and improved cognitive function. Mechanism centers on autophagy induction. A small RCT showed memory improvement in older adults.
Benefits
- Potent autophagy inducer
- Associated with cardiovascular longevity
- May support cognitive function in aging
- Cardioprotective in preclinical models
Dosage notes
1–6 mg daily from wheat germ extract. Dietary intake from aged cheese, mushrooms, and legumes.
Side effects
- Generally well tolerated
- Mild GI symptoms possible
Who should be cautious
Theoretical concern about promoting growth of existing tumors due to polyamine-cancer link, though dietary spermidine data does not support this.
What this page cannot tell you
Most evidence is observational or preclinical. Supplemental doses may not replicate dietary intake patterns. Wheat germ extract is the most common source.
Leaderboard scores
- Longevity60
- Memory40
Featured in protocols
- Longevity Stackadjunct
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