Longevity Stack

Targets hallmarks of aging: NAD+ decline, senescent cell accumulation, mTOR overactivation, and mitochondrial dysfunction. Evidence ranges from robust animal data to emerging human trials. This is a speculative, long-horizon stack — none of these compounds are proven to extend human lifespan. Use with full awareness that the science is early and individual responses vary. Rapamycin especially requires medical supervision.

• nad-boosters

  NMN 250–500 mg or NR 300 mg daily, morning

• resveratrol

  250–500 mg/day with a fat-containing meal

• spermidine

  1–5 mg/day; or wheat germ extract

• fisetin

  100–500 mg/day; intermittent high-dose protocols under study

• quercetin

  500 mg/day; often paired with fisetin in senolytic protocols

• rapamycin

  Low-dose pulsed protocol (e.g. 5–6 mg weekly) — prescription only, requires physician oversight