Match

Melatonin

A hormone produced by the pineal gland that regulates circadian rhythm. One of the most well-studied supplements for sleep onset, jet lag, and circadian rhythm disorders.

Phenibut

A synthetic GABA analog (beta-phenyl-GABA) that crosses the blood-brain barrier and acts on GABA-B receptors. Developed in Russia and used there as an anxiolytic since the 1960s.

Glycine

The simplest amino acid, serving as a neurotransmitter co-agonist at NMDA receptors, a precursor to glutathione, and a structural component of collagen. Studied for sleep, cognition, and metabolic health.

L-Theanine

A non-protein amino acid found predominantly in tea leaves that crosses the blood-brain barrier and promotes alpha-wave activity, supporting calm attentiveness without sedation.

Tryptophan

An essential amino acid and the sole dietary precursor to serotonin and melatonin. Rate-limiting for serotonin synthesis in the brain, making it relevant to mood, sleep, and appetite regulation.

5-HTP

The immediate biosynthetic precursor to serotonin, extracted from Griffonia simplicifolia seeds, used to support mood and sleep.

Magnesium Glycinate

Magnesium bound to the amino acid glycine, offering high bioavailability with minimal laxative effect. The glycine component may independently contribute to calming and sleep-promoting effects.

Ibutamoren (MK-677)

A non-peptide ghrelin receptor agonist (growth hormone secretagogue) that stimulates pulsatile GH and IGF-1 release orally. Studied in elderly, GH-deficient, and obese populations.

Valerian

A root extract used for sleep onset, anxious restlessness, and nighttime tension.

Chamomile

A well-known daisy-family herb used for calm, sleep, and digestive soothing.