Goal picker

Match

Pick a goal. We'll rank compounds by our editorial score for that use case.

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Focus Anxiety Energy Memory Mood Stress Longevity Weight loss Muscle Recovery Libido Pain Immunity Sleep

Ranked for focus

Caffeine
The world's most widely consumed psychoactive substance, a methylxanthine that blocks adenosine receptors to promote wakefulness, focus, and physical performance.
82
Modafinil
A prescription eugeroic (wakefulness-promoting agent) FDA-approved for narcolepsy, shift-work disorder, and obstructive sleep apnea. Widely used off-label for cognitive enhancement.
82
Armodafinil
The R-enantiomer of modafinil, FDA-approved for narcolepsy, obstructive sleep apnea, and shift-work disorder. Longer plasma half-life than racemic modafinil.
80
L-Theanine
A non-protein amino acid found predominantly in tea leaves that crosses the blood-brain barrier and promotes alpha-wave activity, supporting calm attentiveness without sedation.
78
Atomoxetine
A selective norepinephrine reuptake inhibitor (NRI) FDA-approved for ADHD in children and adults. Unlike stimulants, it is not a controlled substance.
70
Adrafinil
A prodrug of modafinil that is converted in the liver to its active metabolite. Originally developed in France for narcolepsy-related drowsiness.
65
L-Tyrosine
A non-essential amino acid and precursor to dopamine, norepinephrine, and epinephrine. Studied for cognitive performance under stress, sleep deprivation, and cold exposure.
65
Alpha-GPC
A phospholipid-derived choline source that efficiently raises brain acetylcholine levels, studied for cognitive support and power output.
60
DHA
Docosahexaenoic acid, a long-chain omega-3 fatty acid critical for brain structure, retinal function, and anti-inflammatory signalling. The dominant omega-3 in neural tissue.
55
Phenylpiracetam
A phenylated piracetam derivative developed in Russia for cosmonauts. Provides both cognitive and physical stimulation. Banned by WADA as a performance enhancer.
55
Acetyl-L-carnitine
An acetylated form of L-carnitine that crosses the blood-brain barrier more readily, studied for cognitive support and mitochondrial function.
50
Phosphatidylserine
Phosphatidylserine is a phospholipid concentrated in brain cell membranes, studied for cognitive support and cortisol modulation.
50
Theacrine
Theacrine is a purine alkaloid structurally similar to caffeine found in kucha tea, providing energy and focus without habituation or tolerance.
50
Citicoline
An endogenous nucleotide (CDP-choline) involved in phosphatidylcholine synthesis. Studied extensively as a neuroprotectant in stroke and for age-related cognitive decline.
50
Huperzine A
A sesquiterpene alkaloid isolated from the club moss Huperzia serrata that potently and reversibly inhibits acetylcholinesterase. Used traditionally in Chinese medicine.
50
Lion's Mane
An edible medicinal mushroom (Hericium erinaceus) containing hericenones and erinacines that stimulate nerve growth factor synthesis in vitro and in animal models.
50
Noopept
A synthetic dipeptide (N-phenylacetyl-L-prolylglycine ethyl ester) developed in Russia, proposed to modulate AMPA and NMDA receptors and increase BDNF/NGF expression.
50
Pramiracetam
A potent racetam with high oral bioavailability and a long half-life (5–6 hours). Stimulates high-affinity choline uptake (HACU) and nitric oxide synthase activity.
50
N-Acetyl L-Tyrosine (NALT)
An acetylated form of L-tyrosine marketed as having superior water solubility and bioavailability. In practice, conversion to free tyrosine appears limited, making it a less efficient precursor.
50