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Ranked for mood

SAMe (S-Adenosylmethionine)
SAMe is a naturally occurring methyl donor involved in neurotransmitter synthesis, joint health, and liver function, with strong clinical evidence for depression and osteoarthritis.
72
St. John's wort
A well-studied antidepressant herb used for mild-to-moderate depressive symptoms.
70
Saffron
A crocus stigma extract with unusually strong evidence for mood support and some appetite-regulation benefit.
65
Hyperforin
The primary active compound in St. John's Wort responsible for its antidepressant effects. It inhibits reuptake of serotonin, norepinephrine, dopamine, GABA, and glutamate.
62
5-HTP
The immediate biosynthetic precursor to serotonin, extracted from Griffonia simplicifolia seeds, used to support mood and sleep.
55
Pyridoxal-5-Phosphate
Pyridoxal-5-phosphate (P5P) is the active coenzyme form of vitamin B6, bypassing hepatic conversion and essential for over 100 enzymatic reactions.
55
Vitamin B8 (Inositol)
Inositol (myo-inositol) is a carbocyclic sugar involved in insulin signaling and serotonin receptor function, with strong evidence for PCOS, anxiety, and panic disorder.
55
Testosterone
The primary male sex hormone and an anabolic steroid. FDA-approved for testosterone replacement therapy (TRT) in hypogonadal men. Critical for muscle mass, bone density, libido, and mood.
55
Tryptophan
An essential amino acid and the sole dietary precursor to serotonin and melatonin. Rate-limiting for serotonin synthesis in the brain, making it relevant to mood, sleep, and appetite regulation.
55
DHA
Docosahexaenoic acid, a long-chain omega-3 fatty acid critical for brain structure, retinal function, and anti-inflammatory signalling. The dominant omega-3 in neural tissue.
50
Omega-3 Fatty Acids
Essential polyunsaturated fatty acids (EPA and DHA) with anti-inflammatory properties. Among the most studied supplements, with evidence spanning cardiovascular, neurological, and inflammatory conditions.
50
Vitamin B Complex
A comprehensive formula providing all eight B vitamins (B1, B2, B3, B5, B6, B7, B9, B12) essential for energy metabolism, nervous system function, and methylation.
50
Vitamin B6 (Pyridoxine)
Pyridoxine is the most common supplemental form of vitamin B6, converted in the liver to the active coenzyme P5P for neurotransmitter synthesis and amino acid metabolism.
50
Phenibut
A synthetic GABA analog (beta-phenyl-GABA) that crosses the blood-brain barrier and acts on GABA-B receptors. Developed in Russia and used there as an anxiolytic since the 1960s.
50
L-DOPA
Levodopa, the immediate biosynthetic precursor to dopamine, is the gold-standard treatment for Parkinson's disease. Always co-administered with a peripheral decarboxylase inhibitor (carbidopa or benserazide).
50