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Ranked for pain

PEA (Palmitoylethanolamide)
Palmitoylethanolamide is an endogenous fatty acid amide that modulates pain and inflammation via PPAR-alpha and mast cell stabilization.
72
SAMe (S-Adenosylmethionine)
SAMe is a naturally occurring methyl donor involved in neurotransmitter synthesis, joint health, and liver function, with strong clinical evidence for depression and osteoarthritis.
60
Colchicine
An ancient alkaloid from Colchicum autumnale used for gout and familial Mediterranean fever. Increasingly studied for cardiovascular risk reduction and as a potential longevity compound due to anti-inflammatory effects.
60
Boswellia
The resin of Boswellia serrata, standardized for boswellic acids, is used for joint pain and inflammatory conditions.
60
Salicin
Salicin is a glucoside found in willow bark that is metabolized to salicylic acid in the body, providing analgesic and anti-inflammatory effects similar to aspirin.
55
Devil's claw
A South African root used for back pain and osteoarthritis, standardized for harpagoside.
55
White willow bark
A salicin-containing bark used for pain and inflammation as a botanical precursor to aspirin-like pharmacology.
55
Alpha-lipoic acid
An endogenous dithiol compound that functions as a cofactor in mitochondrial energy metabolism and as a potent recycler of other antioxidants.
50
Menthol
A cyclic monoterpene alcohol from peppermint oil that activates TRPM8 cold receptors. Used topically for pain relief and orally (as peppermint oil capsules) for IBS symptoms.
50
Vitamin B2 (Riboflavin)
Riboflavin is an essential B vitamin that serves as a precursor to FAD and FMN, coenzymes critical for energy production, antioxidant recycling, and drug metabolism.
50
Agmatine
A biogenic amine produced by decarboxylation of arginine, acting on imidazoline receptors, NMDA receptors, and nitric oxide pathways. Studied for pain, mood, and neuroprotection.
50
Arnica
A topical mountain flower extract used for bruising, soreness, and localized pain relief.
50
Ginger
A warming rhizome with strong traditional and clinical support for nausea, dysmenorrhea, and mild inflammatory pain.
50
Turmeric
A golden rhizome rich in curcuminoids, widely used for pain, inflammation, and cardiometabolic support.
50