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Ranked for anxiety

Phenibut
A synthetic GABA analog (beta-phenyl-GABA) that crosses the blood-brain barrier and acts on GABA-B receptors. Developed in Russia and used there as an anxiolytic since the 1960s.
75
L-Theanine
A non-protein amino acid found predominantly in tea leaves that crosses the blood-brain barrier and promotes alpha-wave activity, supporting calm attentiveness without sedation.
72
Vitamin B8 (Inositol)
Inositol (myo-inositol) is a carbocyclic sugar involved in insulin signaling and serotonin receptor function, with strong evidence for PCOS, anxiety, and panic disorder.
65
Kava
A Pacific root beverage used for anxiety, stress, and social relaxation through kavalactone-rich extracts.
65
Ashwagandha
A root adaptogen used for stress resilience, sleep quality, strength support, and perceived recovery.
60
Magnesium Glycinate
Magnesium bound to the amino acid glycine, offering high bioavailability with minimal laxative effect. The glycine component may independently contribute to calming and sleep-promoting effects.
50
Bromantane
A synthetic adamantane derivative developed in Russia as an actoprotector — a class intended to enhance physical performance without stimulant side effects. Also studied for anxiolytic properties.
50
Aniracetam
A fat-soluble racetam and AMPAkine that modulates AMPA receptors and metabotropic cholinergic transmission. Approved in some European countries for cognitive disorders.
50
Lavender
A fragrant herb used as tea, essential oil, and oral extract for anxiety, stress, and sleep quality.
50