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Ranked for longevity

EPA
Eicosapentaenoic acid, a long-chain omega-3 fatty acid with potent anti-inflammatory and cardiovascular benefits. The primary therapeutic omega-3 for triglyceride reduction.
70
Omega-3 Fatty Acids
Essential polyunsaturated fatty acids (EPA and DHA) with anti-inflammatory properties. Among the most studied supplements, with evidence spanning cardiovascular, neurological, and inflammatory conditions.
70
Vitamin D3 (Cholecalciferol)
Vitamin D3 is the most effective supplemental form of vitamin D, essential for calcium absorption, bone health, immune modulation, and increasingly linked to reduced mortality.
70
Rapamycin
An mTOR inhibitor (sirolimus) FDA-approved as an immunosuppressant for organ transplant rejection. The most studied pharmaceutical candidate for lifespan extension, with consistent effects across multiple species.
70
Cocoa flavanols
Epicatechin-rich polyphenols from cacao that improve endothelial function, blood flow, and cardiovascular biomarkers in well-designed trials.
65
Red Yeast Rice
Red yeast rice contains monacolin K, which is chemically identical to lovastatin, and effectively lowers LDL cholesterol.
65
Sulforaphane
Sulforaphane is an isothiocyanate derived from broccoli sprouts that potently activates Nrf2, the master regulator of cellular antioxidant defenses and detoxification enzymes.
65
Urolithin A
Urolithin A is a gut-derived metabolite of ellagitannins (from pomegranates) that potently induces mitophagy and has demonstrated muscle health benefits in human trials.
65
CoQ10
Ubiquinone/ubiquinol, a lipid-soluble coenzyme essential for mitochondrial electron transport and a potent endogenous antioxidant. Levels decline with age and statin use.
62
DHA
Docosahexaenoic acid, a long-chain omega-3 fatty acid critical for brain structure, retinal function, and anti-inflammatory signalling. The dominant omega-3 in neural tissue.
60
Oleic Acid
The primary monounsaturated fatty acid in olive oil. A cornerstone of the Mediterranean diet associated with cardiovascular health, reduced inflammation, and improved lipid profiles.
60
Quercetin
Quercetin is a widely distributed flavonoid with antioxidant, anti-inflammatory, and senolytic properties, found in onions, apples, and berries.
60
Quercetin Phytosome
Quercetin phytosome is a phospholipid-complexed form of quercetin with dramatically improved bioavailability compared to standard quercetin.
60
Spermidine
Spermidine is a natural polyamine that induces autophagy and is associated with longevity in observational studies across multiple populations.
60
Taurine
Taurine is a conditionally essential sulfur amino acid abundant in brain, heart, and muscle tissue, with roles in osmoregulation, antioxidant defense, and cardiovascular function.
60
Vitamin K (MK-7)
Vitamin K2 (menaquinone-7) is the preferred supplemental form for bone and cardiovascular health, activating osteocalcin and matrix Gla protein to direct calcium appropriately.
60
Alpha-lipoic acid
An endogenous dithiol compound that functions as a cofactor in mitochondrial energy metabolism and as a potent recycler of other antioxidants.
55
Hydroxytyrosol
A potent polyphenol antioxidant found in olive oil and olive leaf. It has one of the highest ORAC values of any natural compound and is linked to cardiovascular and neuroprotective benefits.
55
Lutein
A carotenoid that accumulates in the macula of the eye, providing protection against blue light and oxidative damage. One of the best-studied nutrients for age-related macular degeneration.
55
Menaquinone-7 (Vitamin K2 MK-7)
The most bioavailable and long-acting form of vitamin K2. Activates proteins that direct calcium into bones and away from arteries, supporting both skeletal and cardiovascular health.
55
NAC (N-Acetyl Cysteine)
A precursor to glutathione and a mucolytic agent. One of the most versatile supplements with applications ranging from liver protection to psychiatric conditions and respiratory health.
55
NAD+ Boosters (NMN/NR)
Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are precursors to NAD+, a coenzyme critical for energy metabolism, DNA repair, and sirtuin activation that declines with age.
55
Phylloquinone (Vitamin K1)
Phylloquinone (vitamin K1) is the plant-derived form of vitamin K, essential for blood clotting and bone metabolism.
55
Pterostilbene
Pterostilbene is a dimethylated analog of resveratrol found in blueberries, with superior bioavailability and similar sirtuin-activating and antioxidant properties.
55
Pycnogenol
Pycnogenol is a standardized extract of French maritime pine bark rich in procyanidins, with extensive clinical research on circulation, inflammation, and skin health.
55
R-Alpha Lipoic Acid
R-alpha lipoic acid is the biologically active enantiomer of alpha-lipoic acid, a potent antioxidant that regenerates other antioxidants and supports glucose metabolism.
55
TUDCA
Tauroursodeoxycholic acid (TUDCA) is a water-soluble bile acid with potent hepatoprotective, neuroprotective, and ER stress-reducing properties.
55
UDCA (Ursodeoxycholic Acid)
Ursodeoxycholic acid (UDCA) is a hydrophilic bile acid used as first-line treatment for primary biliary cholangitis and studied for broader liver and gallbladder conditions.
55
Vitamin B3 (Niacin)
Niacin is an essential B vitamin and NAD+ precursor available in multiple forms (nicotinic acid, niacinamide, NR, NMN), each with distinct clinical profiles.
55
Ergocalciferol (Vitamin D2)
Ergocalciferol (vitamin D2) is the plant-derived form of vitamin D, less effective than D3 at raising and maintaining serum 25(OH)D levels.
55
Colchicine
An ancient alkaloid from Colchicum autumnale used for gout and familial Mediterranean fever. Increasingly studied for cardiovascular risk reduction and as a potential longevity compound due to anti-inflammatory effects.
55
Semaglutide
A once-weekly GLP-1 receptor agonist FDA-approved for type 2 diabetes (Ozempic), obesity (Wegovy), and available in oral form (Rybelsus). Demonstrated cardiovascular and renal benefits.
55
Alpha-ketoglutarate (AKG)
A Krebs-cycle intermediate involved in energy metabolism, amino acid synthesis, and epigenetic regulation, investigated for longevity effects.
50
Berberine
An isoquinoline alkaloid from plants like goldenseal and barberry that activates AMPK, with glucose- and lipid-lowering effects comparable to some pharmaceuticals.
50
Calcium alpha-ketoglutarate
The calcium salt of AKG used in the Rejuvant longevity trial, providing both AKG for Krebs-cycle support and a modest calcium contribution.
50
Glutathione
The body's master antioxidant, a tripeptide critical for detoxification, immune function, and cellular protection. Oral bioavailability has historically been poor, though liposomal and reduced forms may improve absorption.
50
Lycopene
A red carotenoid pigment abundant in tomatoes and watermelon. Epidemiological studies consistently associate higher lycopene intake with reduced prostate cancer risk and cardiovascular benefit.
50
Phosphatidylcholine
Phosphatidylcholine is a major phospholipid in cell membranes and a source of choline, supporting liver function and cell membrane integrity.
50
PQQ (Pyrroloquinoline Quinone)
PQQ is a redox cofactor that supports mitochondrial biogenesis and protects neurons from oxidative damage.
50
Punicalagins
Punicalagins are ellagitannin polyphenols from pomegranate, responsible for much of its antioxidant activity and metabolized to urolithins by gut bacteria.
50
Resveratrol
Resveratrol is a stilbenoid polyphenol from grapes and red wine, extensively studied for sirtuin activation, cardiovascular protection, and longevity.
50
Selenium
Selenium is an essential trace mineral incorporated into selenoproteins that are critical for antioxidant defense, thyroid function, and immune regulation.
50
Selenomethionine
Selenomethionine is the primary organic form of selenium found in food, offering superior absorption and tissue storage compared to inorganic selenium.
50
Silybin
Silybin (silibinin) is the most active flavonolignan in milk thistle (silymarin), with hepatoprotective, antioxidant, and emerging anticancer properties.
50
Tocotrienols
Tocotrienols are the lesser-known form of vitamin E with unique neuroprotective, cardiovascular, and anti-inflammatory properties not shared by tocopherols.
50
Trans-Resveratrol
Trans-resveratrol is the biologically active isomer of resveratrol, preferred in supplementation for its stability and SIRT1-activating capacity.
50
Vitamin B9 (Folate)
Folate is an essential B vitamin required for DNA synthesis, methylation, and neural tube development. Methylfolate (5-MTHF) is the biologically active form.
50
Zeaxanthin
Zeaxanthin is a carotenoid pigment concentrated in the macula of the eye, where it filters blue light and provides antioxidant protection against age-related macular degeneration.
50
Everolimus
An mTOR inhibitor (rapalog) FDA-approved for organ transplant rejection, certain cancers, and tuberous sclerosis. Studied for immunosenescence reversal and longevity at low doses.
50
Tirzepatide
A dual GLP-1/GIP receptor agonist (Mounjaro for diabetes, Zepbound for obesity) that demonstrated weight loss exceeding 20% in the SURMOUNT trials, surpassing GLP-1 monotherapy.
50
Glycine
The simplest amino acid, serving as a neurotransmitter co-agonist at NMDA receptors, a precursor to glutathione, and a structural component of collagen. Studied for sleep, cognition, and metabolic health.
50